Bcr-Abl Kinase
A tyrosine kinase enzyme that is the product of the fusion gene created by the Philadelphia chromosome translocation in chronic myeloid leukemia.
Bcr-Abl Inhibitors
A class of drugs used to treat chronic myeloid leukemia that target the Bcr-Abl tyrosine kinase enzyme.
Bcr-Abl Mutation
A change in the DNA sequence of the Bcr-Abl gene that can lead to resistance to Bcr-Abl inhibitors.
Bcr-Abl Translocation
A genetic abnormality that occurs in chronic myeloid leukemia, in which the Bcr gene on chromosome 22 is translocated to the Abl gene on chromosome 9.